fig6

Figure 6. Acetylation and deacetylation fine-tune EGFR trafficking and degradation. Acetylation of EGFR by acetyltransferases such as CBP enhances receptor phosphorylation and signaling. A key regulatory mechanism involves HDAC6, a deacetylase that acts on α-tubulin. HDAC6-mediated deacetylation of microtubules delays the trafficking of EGFR from early endosomes to late endosomes/lysosomes, thereby impeding receptor degradation and potentially sustaining signaling. EGFR: Epidermal growth factor receptor; CBP: CREB-binding protein; HDAC6: histone deacetylase 6.