fig3

Figure 3. PCoA visualization for the comparison of the nucleotide pool in BMMC depending on (A) genetic subgroups; (B) karyotype; and (C) ELN classification. Favorable genomic group was defined as NPM1mut, CEBPA bZIP mutations or CBF-rearrangements. PCoA: Principal coordinate analysis; BMMC: bone marrow mononuclear cells; ELN: European LeukemiaNet; CEBPA: CCAAT/enhancer-binding protein alpha; CBF: core binding factors; KMT2A: lysine (K)-specific methyltransferase 2A.