fig2

Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression

Figure 2. THZ2 induces dual cytotoxic effects in GBM cells: cell cycle arrest and apoptosis. (A and B) Effects of 0.25 μM THZ2 for 48 h on cell cycle distribution (A) and apoptosis (B) in A172, U118MG, U87MG, and U251 cells. Data are presented as mean ± SD from three independent experiments (n = 3). ns: Not significant; **P < 0.01; ***P < 0.001. Statistical significance was assessed using Student’s t-test. GBM: Glioblastoma; SD: standard deviation.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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