fig4

Figure 4. Dendrimer-based hydrogel for bone regeneration. Dendritic crosslinkers regulate hydrogel mechanics, porosity and the presentation or release of osteogenic cues. These properties can support stem cell recruitment and differentiation, vascularization and bone formation. YAP: Yes-associated protein; hMSC: human mesenchymal stromal cells; ROS: reactive oxygen species; BMP: bone morphogenetic protein; ALP: alkaline phosphatase; OPN: osteopontin; OCN: osteocalcin; GIT1: G protein-coupled receptor kinase-interacting protein 1.