fig5

Figure 5. Functional enrichment and PPI network analyses of BCAA-related proteins. (A) GO enrichment analysis of the consensus proteins. For visualization purposes, only the top 10 significantly enriched terms with the highest fold enrichment are displayed across biological process, cellular component, and molecular function categories; (B) KEGG pathway enrichment analysis of the consensus proteins; (C) PPI network constructed from 28 proteins mapped to the significantly enriched KEGG pathway. Proteins are clustered (from left to right, top to bottom) into three functional modules: positive regulation of receptor signaling pathway via STAT, nitrogen metabolism, and branched-chain amino acid catabolism. Unconnected nodes were excluded. BCAA: Branched-chain amino acid; CoA: coenzyme A; FDR: false discovery rate; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; PPI: protein-protein interaction; STAT: signal transducer and activator of transcription.