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Figure 5. Stimuli-responsive hydrogels for combinational therapy of ocular tumors. (A) Schematic of an injectable composite hydrogel co-encapsulating an oncolytic adenovirus and melphalan for retinoblastoma treatment. Figure 5A is quoted with permission from Wang et al.^[161] under the CC BY-NC-ND license without modification; (B) Fabrication and near-infrared light-induced gel-sol transition of the CP@Au@DC_AC50 hydrogel for uveal melanoma therapy; (C) Multifunctional properties of the CP@Au@DC_AC50 hydrogel, integrating gene-targeted therapy, mild photothermal therapy, and antibacterial activity. Figure 5B and C are quoted with permission from Wang et al.^[164]. Col: Collagen; Mel: melphalan; CDA: β-cyclodextrin aldehyde; OA: oncolytic adenovirus; RB: retinoblastoma; CP: chitosan@puerarin; GNR: gold nanorod; ATOX1: antioxidant 1 Copper Chaperone; NIR: near-infrared; PTT: photothermal therapy; DC_AC50: a small-molecule inhibitor of ATOX1; CCA: collagen-based hydrogel with cyclodextrin aldehyde