fig3

From: Stimuli-responsive hydrogels for ocular tumor therapy

Figure 3. Stimuli-responsive hydrogels for ocular tumor chemotherapy. (A) Schematic illustration of the synthesis of a dendrimer hydrogel carrying melphalan in both conjugated and free forms and its application for retinoblastoma. Figure 3A is quoted with permission from Cooper et al.^[147]; (B) Application of RENP-ICG@PNIPAM: Dox-FA in choroidal melanoma therapy. Figure 3B is quoted with permission from Li et al.^[150]; (C) Fabrication process of a bilayer hydrogel microrobot; (D) Scheme of the therapeutic action of the bilayer hydrogel microrobot against Y79 retinoblastoma cells. Figure 3C and D is quoted with permission from Kim et al.^[151]. DH: Dendrimer hydrogel; GSH: glutathione; TME: tumor microenvironment; NIR: near infrared; RENP: rare-earth nanoparticle; ICG: indocyanine green; PNIPAM: poly(N-isopropylacrylamide); PEGDA: poly(ethylene glycol) diacrylate; FA: folic acid; PLGA: poly(lactic-co-glycolic acid); PVA: polyvinyl alcohol; MNP: magnetic nanoparticle; AMF: alternating magnetic field.