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Figure 5. Schematic of precise activation strategies and delivery-degradation process for nano-TPD systems. (A) Left panel: Responsive conditions and responsive process of the Dual Endogenous Signal-responsive nano-TPD Systems; Right panel: Responsive conditions and responsive process of the Endogenous-Exogenous Combined Activation nano-TPD Systems; (B) Overall flowchart of the Multi-conditionally responsive nano-TPD Systems. FigDraw ID:TUTPRf5a0d. TPD: Targeted protein degradation; UPS: ubiquitin-proteasome system; POI: protein of interest; ROS: reactive oxygen species; EPR: enhanced permeability and retention; TME: tumor microenvironment.