fig2

Figure 2. Current controversies defining the boundaries of ferroptosis.
The ten controversies discussed in this review are grouped into four interconnected domains: mechanistic definition, regulatory control, experimental interpretation, and translational relevance. These debates encompass questions regarding the identity and execution of ferroptosis, the pathways that govern ferroptosis susceptibility, the criteria used for its experimental attribution, and its significance in disease and therapeutic intervention. GPX4: Glutathione peroxidase 4.