fig2

Figure 2. Mouse treatment schedule and water maze data results. (A) Stereotaxic injection diagram; (B) Escape latency time during the training stage; (C) Percentage of time spent in the target quadrant; (D) Number of times crossing over the platform area on the sixth day. The data are presented as the mean ± SEM. ^*P < 0.05, ^**P < 0.01, APP/PS1+hSyn-Con vs. WT-hSyn-Con; ^#P < 0.05, APP/PS1+hSyn-shTMPRSS6 vs. APP/PS1+hSyn-Con, ns: not significant. SEM: Standard error of the mean; APP: amyloid precursor protein; WT: wild-type.