fig3

Figure 3. TCGA- HCC molecular subtypes based on PRGs and their characteristics. (A) Volcano plot of DEGs between the two subtypes in the TCGA cohort. The yellow dots represent upregulated DEGs, the blue dots indicate downregulated DEGs, and the grey dots stand for undifferentiated expression genes. (B) Heatmap of PRGs between the subtype C1 and subtype C2. (C) The ESTIMATE score, immune score, and stromal score demonstrate the distinct immune statuses between the two subtypes. (D) Boxplots showing the drug sensitivity of Axitinib, Bosutinib, Erlotinib, and Gefitinib between the two subtypes. (E and F) Oncoplot displaying the somatic landscape of HCC with subtypes C1 (E) and C2 (F). 15 genes were sorted with the highest mutation. ****P < 0.0001.