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Figure 1. Genetic alterations and expression patterns of PRGs in HCC. (A and B) Boxplots showing the FPKM expression levels of PRGs in normal versus HCC samples. Tumor, yellow; Normal, blue. (C) Metascape visualization of the networks of the top 20 clusters. Each node represents an enriched term, with node color indicating the cluster ID. Nodes within the same cluster tend to be spatially proximate. Node size reflects the number of input genes associated with the term, and thicker edges indicate greater similarity between terms. (D) Mutation frequency and classification of 37 differentially expressed pyroptosis-related DEGs in 364 HCC patients. (E) Heatmap of the correlation matrix showing pairwise correlations among the 37 DEG. (F) PPI network of the 37 DEGs generated using the STRING database. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.