Topic: Emerging Technologies Targeting Vascular Pathologies: Basic Mechanisms and Clinical Translation

Vascular pathologies, encompassing conditions such as atherosclerosis, aneurysms, and thromboembolic diseases, represent a major global health challenge with rising morbidity and mortality. Despite advances in conventional therapies, significant gaps remain in understanding disease mechanisms and translating discoveries into effective clinical interventions. This Special Issue focuses on emerging technologies that bridge basic science and clinical practice, offering transformative potential for diagnosing, treating, and preventing vascular diseases.

Innovations such as nanotechnology, artificial intelligence (AI)-driven diagnostics, molecular imaging, gene-editing tools, and 3D bioprinting are revolutionizing our approach to vascular pathologies. However, challenges persist in elucidating their mechanistic underpinnings, optimizing translational workflows, and addressing ethical and regulatory considerations. This issue emphasizes interdisciplinary collaboration, highlighting studies that integrate cutting-edge technologies with mechanistic insights to accelerate clinical translation. Topics span from molecular-level discoveries (e.g., endothelial dysfunction, immune-metabolic crosstalk) to patient-centric applications (e.g., personalized therapies, real-world clinical validation). By fostering dialogue among researchers, clinicians, and bioengineers, this Special Issue aims to catalyze breakthroughs that redefine vascular medicine and improve global health outcomes.

Recommended topics for the special issue include:
1. Novel Imaging Modalities: High-resolution molecular imaging, AI-enhanced diagnostics, and intravascular ultrasound for early disease detection.

2. Nanotechnology in Vascular Therapy: Targeted drug delivery, nanomaterial-based vascular repair, and biocompatibility challenges.

3. Gene and Cell-Based Therapies: Gene-editing/Virus applications, cell therapy, and regenerative medicine for vascular disease.

4. Computational Modeling and AI: Predictive algorithms for disease progression, machine learning in plaque characterization, and digital twins for surgical planning.

5. 3D Bioprinting and Tissue Engineering: Biofabrication of functional vasculature, in vitro disease models, and translational hurdles.

6. Immune-Metabolic Interactions: Role of inflammation, microbiome, and metabolic reprogramming in vascular pathologies.

7. Precision Medicine Approaches: Biomarker discovery, pharmacogenomics, and sex-specific therapeutic strategies.

8. Clinical Translation Challenges: Regulatory frameworks, scalability of technologies, and real-world efficacy trials.

9. Wearable and Remote Monitoring Devices: Smart sensors for continuous vascular health tracking and telehealth integration.

10. Emerging Therapeutics: RNA-based therapies, mitochondrial-targeted interventions, and immunomodulatory agents.

Vascular diseases, translational medicine, nanotechnology, artificial intelligence, gene and cell therapy, 3d bioprinting, molecular imaging, precision medicine, immune-metabolic crosstalk, wearable devices