fig6

Figure 6. Mediation analysis centered on BrainSegVol-to-eTIV and HLA-DRB1. (A) Scatter plot and leave-one-out analysis for BrainSegVol-to-eTIV on OP; (B) Scatter plot and leave-one-out analysis for BrainSegVol-to-eTIV on HLA-DRB1; (C) Scatter plot and leave-one-out analysis for HLA-DRB1 on OP; (D) Colocalization result for HLA-DRB1; (E) Indirect-effect estimate and mediation proportion for the HLA-DRB1 pathway. MR: Mendelian randomization; HLA-DRB1: human leukocyte antigen - DRB1; OP: osteoporosis; GWAS: genome-wide association studies.