fig3

Figure 3. Mendelian randomization analysis for BMD on EAA. nSNP: the number of single-nucleotide polymorphisms; IVW: inverse-variance weighted; EAA: epigenetic age acceleration; IEAA: intrinsic epigenetic age acceleration; HannumAA: Hannum Age acceleration; PhenoAA: PhenoAge acceleration; GrimAA: GrimAge acceleration; BMD: bone mineral density; FN BMD: femoral neck BMD; LS BMD: lumbar spine BMD; FA BMD: forearm BMD; eBMD: heel-BMD; TB BMD: total body BMD; OR: odds ratio; 95%CI: 95% confidence interval; P: P-value.