fig3

Figure 3. Optimization analysis of the IRGS model. (A) Nomogram analysis combining clinical factors with the IRGS model, (B) Calibration analysis of the model's predictive performance when including only clinical factors, (C) Calibration analysis of the optimized model's performance when combining clinical factors with the IRGS model. The total risk score is calculated by summing the points assigned to each variable, and the combined score is then projected onto the 1-, 2-, and 3-year survival axes. (e.g., Age = 60 years → 50 points; IRGS = High → 0 points; Stage = III → 50 points, Total score = 100 points, corresponding to a predicted 1-year OS probability of ~82%.)